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A University of Queensland medical student has been awarded a prestigious fellowship to research the debilitating nervous system disorder, Parkinson's Disease.

Zhen-Yi Andy Ou, a research assistant with the (UQCCR), will use his to investigate how best to limit chronic brain inflammation and neurotoxicity in Parkinson’s patients.

There are currently limited treatments for Parkinson’s and no effective way to slow or stop the disease, which results in progressive disability for most patients.

Mr Ou said chronic ongoing inflammation was believed to contribute to a loss of dopamine neurons that control brain function, leading to the progression of the disease.

“Under the guidance of , UQCCR researchers recently discovered new mechanisms that regulate the protein NLRP3 inflammasome, a key driver of inflammation and Parkinson’s progression,” Mr Ou said.

“Reducing inflammation and neuronal death is considered one of the most promising therapeutic approaches to slow or halt of Parkinson’s.”

Mr Ou’s research will use a new approach which targets multiple mechanisms and pathways involved in regulating inflammatory responses in the brain.

“Most therapeutic strategies used to target inflammation in Parkinson’s aim to block a single inflammatory pathway but this approach has had limited success in clinical trials to date,” he said.

Mr Ou is currently studying his MD at University of Queensland and his fellowship will be under the mentorship of .

Media: Mr Andy Ou, a.ou@uq.edu.au, or med.media@uq.edu.u, or +61 7 3365 5118